Senin, 24 Desember 2012

Ascariasis

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Ascariasis

Definition  :
Ascariasis

Ascariasis (as-kuh-RIE-uh-sis) is a type of roundworm infection. These worms are parasites that use your body as a host to mature from larvae or eggs to adult worms and reproduce. Adult worms can be more than a foot (30 centimeters) long.

Ascariasis is one of the most common human worm infections worldwide, although it's uncommon in the United States. Because most people have such mild cases of ascariasis, they have no symptoms. But when your body is infested with hundreds of worms, serious symptoms and complications can occur.

Ascariasis occurs most often in young children and is most prevalent in tropical and subtropical regions of the world — especially in areas where sanitation and hygiene are poor. In the United States, ascariasis is most likely to occur in rural areas of the Southeast.


Symptoms:

Most people infected with ascariasis have no symptoms. Moderate to heavy infestations cause symptoms that may vary, depending on which part of your body is affected.

In the lungs
After you ingest the microscopic ascariasis eggs, they hatch in your small intestine and the larvae migrate through your bloodstream or lymphatic system into your lungs. At this stage, you may experience signs and symptoms similar to asthma or pneumonia, including:
  • Persistent cough
  • Shortness of breath
  • Wheezing
After spending six to 10 days in the lungs, the larvae travel to your throat, where you cough them up and then swallow them.

In the intestines
The larvae mature into adult worms in your small intestine, and the adult worms typically live in the intestines until they die. In mild or moderate ascariasis, the intestinal infestation can cause:
  • Vague abdominal pain
  • Nausea and vomiting
  • Diarrhea or bloody stools
If you have a heavy intestinal infestation — a large number of worms — you may experience:
  • Severe abdominal pain
  • Fatigue
  • Vomiting
  • Weight loss
  • A worm in vomit or stool
When to see a doctor
Consult your doctor if you have persistent abdominal pain, diarrhea or nausea.


Causes:

Ascariasis isn't spread directly from person to person. Instead, a person has to come into contact with soil mixed with human feces that contain ascaris eggs. In many developing countries, human feces are used for fertilizer or poor sanitary facilities allow human waste to mix with local soil in yards, ditches and fields.

Because small children often play in dirt, infection can occur if they put their dirty fingers in their mouths. Unwashed fruits or vegetables grown in contaminated soil also can transmit the microscopic eggs that cause ascariasis.
Life cycle of a worm
  • Ingestion. The microscopic ascariasis eggs can't become infective without coming into contact with soil. People can accidentally ingest contaminated soil through hand-to-mouth contact or by eating uncooked fruits or vegetables that have been grown in contaminated soil.
  • Migration. Larvae hatch from the eggs in your small intestine and then penetrate the intestinal wall to travel to your lungs via your bloodstream or lymphatic system. After maturing for about a week in your lungs, the larvae break into your airway and travel up your throat, where they're coughed up and swallowed.
  • Maturation. Once back in the intestines, the parasites grow into male or female worms. Female worms can be more than 15 inches (40 centimeters) long and a little less than a quarter inch (6 millimeters) in diameter. Male worms are generally smaller.
  • Reproduction. Male and female worms mate in the small intestine. Female worms can produce 200,000 eggs a day. You expel the eggs in your feces. The fertilized eggs must be in soil for at least 18 days before they become infective.
The whole process — from egg ingestion to egg deposits — takes about two or three months. Ascariasis worms can live inside you for a year or two.


Complications:

Mild cases of ascariasis usually don't cause complications. If you have a heavy infestation, potentially dangerous complications may include:
  • Nutritional deficiencies. Children with ascariasis are especially at risk of nutritional deficiencies. Loss of appetite and insufficient absorption of digested foods can occur. 
  • Intestinal blockage and perforation. In heavy ascariasis infestation, a mass of worms can block a portion of your intestine, causing severe abdominal cramping and vomiting. The blockage can even perforate the intestinal wall or appendix, causing internal bleeding (hemorrhage ) or appendicitis.
  • Duct blockages. In some cases, worms may block the narrow ducts of your liver or pancreas, causing severe pain. 
Treatments and drugs:

While symptomatic infections usually warrant treatment, infections with no symptoms typically don't need to be treated. In some cases, ascariasis will resolve on its own. This occurs when there are no male worms to mate with females, and the females eventually die.

Medications
Anti-parasite medications are the first line of treatment against ascariasis. The most common are:
  • Albendazole (Albenza)
  • Ivermectin (Stromectol)
  • Mebendazole
These medications work by killing the adult worms. Each medication can be taken as a single dose. Side effects include mild abdominal pain or diarrhea.

Surgery
In cases of heavy infestation, surgery may be necessary to repair damage the worms have caused and to remove worms. Intestinal obstruction or perforation, bile duct obstruction, and appendicitis are complications that may require surgery.

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